Sarver Heart Center, Room 4137
Qin M. Chen, Ph.D.
Nrf2 for Cardiac Protection: the Complexity of the Human Genome, Disease and Aging
Dr. Chen received her Ph.D. degree in Cell Biology and Biochemistry from Clarkson University, Potsdam, New York, and postdoctoral training in the Division of Biochemistry and Molecular Biology at the University of California Berkeley. She was recruited to the University of Arizona in 1996 as a tenure-tracked assistant professor, where she was promoted to full professor in 2009 in the Department of Pharmacology, College of Medicine. Her laboratory has been funded by NIH grants for the past 20 years for investigation on oxidative stress induced cardiac cell injury and cell survival responses involving de novo Nrf2 protein translation. Nrf2 gene encodes a transcription factor best known for regulating the expression of antioxidant and detoxification genes. Recent works have shown that Nrf2 also plays a role in mitochondrial preservation and expression of genes participating in signaling, transcription, anabolic metabolism, cell proliferation, and extracellular matrix remodeling. Dr. Chen will present the data from her laboratory for utilizing Nrf2 as a target for cardiac protection, discussing the complexity of Nrf2 gene in the Human Genome, and revealing the effect of aging or excise on Nrf2 gene expression.